Publications:

Articles:


1

Mazurek A.H., Szeleszczuk Ł,. Bethanis K., Christoforides E., Dudek M.K., Zielińska-Pisklak M., Pisklak D.M. (2023). 17-β-Estradiol—β-Cyclodextrin Complex as Solid: Synthesis, Structural and Physicochemical Characterization. 

Molecules, 28(9):3747

https://doi.org/10.3390/molecules28093747

  
2

Christoforides E., Andreou A., Papaioannou A. and Bethanis K.(2022). Structural studies of piperine inclusion complexes in native and derivative β-cyclodextrins.

Biomolecules, 12(12), 1762

https://doi.org/10.3390/biom12121762

  
3

Bethanis K., Christoforides E., Andreou A. and Eliopoulos E. (2022). Molecular Symmetry of Permethylated β-Cyclodextrins upon Complexation.

Symmetry, 14(10), 2214.

https://doi.org/10.3390/sym14012214

  
4

Hatziagapiou K., Bethanis K., Koniari E., Christoforides E., Nikola O., Andreou A., Mantzou A., Chrousos G. P., Kanaka-Gantennbein C. and Lambrou G. I. (2022). Biophysical Studies and In Vitro Effects of Tumor Cell Lines of Cannabidiol and Its Cyclodextrin Inclusion Complexes.

Pharmaceutics, 14(4), 706.

https://doi.org/10.3390/pharmaceutics14040706

 

  
5

Politi M. E., Bethanis K., Thireou T. and Christoforides E. (2021). Glycosidic vs. Aglycol Form of Natural Products as Putative Tyrosinase Inhibitors

Biophysica, 1(4), 458-473.

https://doi.org/10.3390/biophysica1040033

  
6

Papageorgiou L., Andreou A., Christoforides E., Bethanis K., Vlachakis D., Thireou T. and Eliopoulos E. (2022). Hippo(crates): An integrated atlas for natural product exploration through a state‑of‑the art pipeline in chemoinformatics.

World Academy of Sciences Journal, 4, no. 1: 1.

https://doi.org/10.3892/wasj.2021.136

  
7

Fourtaka K., Christoforides E., Tzamalis P. and Bethanis K. (2021). Inclusion of citral isomers in native and methylated cyclodextrins: Structural insights by X-ray Crystallography and Molecular Dynamics simulation analysis.

Journal of Molecular Structure, 1234, 130169.

https://doi.org/10.1016/j.molstruc.2021.130169

  
8

 

Papaioannou A., Christoforides E., and Bethanis K. (2020). Inclusion complexes of naringenin in dimethylated and permethylated β-cyclodextrins: X-ray crystallography and molecular dynamics studies.

Crystals, 10(1): 10.

https://doi.org/10.3390/cryst10010010 

  
9

Christoforides E., Fourtaka K., Andreou A. and Bethanis K. (2020). X-ray crystallography and molecular dynamics studies of the inclusion complexes of geraniol in β-cyclodextrin, heptakis(2,6-di-O-methyl)-β-cyclodextrin and heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin.

Journal of Molecular Structure, 1202, 127350.

https://doi.org/10.1016/j.molstruc.2019.127350

  
10

Andreou A., Giastas P., Christoforides E. and Eliopoulos E. (2018). Structural and Evolutionary insights within the Polysaccharide Deacetylase Gene Family of Bacillus anthracis and Bacillus cereus.

Genes, 9(8):386.

https://doi.org/10.3390/genes9080386

  
11

Bethanis K., Christoforides E., Tsorteki F., Fourtaka K. and Mentzafos D. (2018). Structural studies of the inclusion compounds of a-naphthaleneacetic acid in heptakis(2,6-di-O-methyl)-β-Cyclodextrin and heptakis(2,3,6-tri-O-methyl)-β-Cyclodextrin by X-ray crystallography and molecular dynamics.

Journal of Inclusion Phenomena and Macrocyclic Chemistry, 92(1), 157-171.

https://doi.org/10.1007/s10847-018-0824-y

  
12

Fourtaka K., Christoforides E., Mentzafos D. and Bethanis K. (2018). Crystal structures and molecular dynamics studies of the inclusion compounds of β-citronellol in β-cyclodextrin, heptakis(2,6-di-O-methyl)-β-cyclodextrin and heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin.

Journal of Molecular Structure, 1161, 1–8.

https://doi.org/10.1016/j.molstruc.2018.02.037

  
13

Christoforides E., Papaioannou A. and Bethanis K. (2018). Crystal structure of the inclusion complex of cholesterol in β-cyclodextrin and molecular dynamics studies.

Beilstein Journal of Organic Chemistry, 14, 838–848. 

doi:10.3762/bjoc.14.69  

  
14



Hatziagapiou K., Bethanis K., Lambrou G. I., Yannakopoulou K., Karpusas M., Braoudaki M., Christoforides E., Tsorteki F., Milionis V., Kavantzas N., Tzortzatou-Stathopoulou F. and Gemou-Engesaeth V. (2017). Enhanced Gefitinib Cytotoxicity in the Presence of Cyclodextrins: In-Vitro and Biophysical Studies Towards Potential Therapeutic Interventions for Cancer.

Journal of Biomedical Nanotechnology, 13(5), 522–533.

https://doi.org/doi:10.1166/jbn.2017.2374

  
15

Christoforides E., Mentzafos D. and Bethanis K. (2015). Structural studies of the inclusion complexes of the (+)- and (−)-borneol enantiomers in α- and β-cyclodextrin.

Journal of Inclusion Phenomena and Macrocyclic Chemistry, 81(1), 193–203.

https://doi.org/10.1007/s10847-014-0448-9

  
16

Bethanis K., Tzamalis P., Tsorteki F., Kokkinou A., Christoforides E. and Mentzafos D. (2013). Structural study of the inclusion compounds of thymol, carvacrol and eugenol in β-cyclodextrin by X-ray crystallography.

Journal of Inclusion Phenomena and Macrocyclic Chemistry, 77(1), 163–173.

https://doi.org/10.1007/s10847-012-0230-9

  
17

Christoforides E., Dimou M., Katinakis P., Bethanis K. and Karpusas M. (2012). Structure of a bacterial cytoplasmic cyclophilin-A in complex with a tetrapeptide.

Acta Crystallographica Section F, 68(3), 259–264. [Cover Page]

https://doi.org/10.1107/S1744309112000188

 

  
    h-index: 9 (Scopus)  


 

Book Chapters:

1

 

 

 

Elias Christoforides and Kostas Bethanis (2019). Chapter 3. Molecular Dynamics Studies of Cyclodextrin Inclusion Compounds, In book: An Introduction to Molecular Dynamics. 

Mark S. Kemp (Editor) Publisher: Nova Science Publishers, Inc., ISBN: 978-1-53616-054-3, pp109-142.

URL: https://novapublishers.com/shop/an-introduction-to-molecular-dynamics/
 

 

 

Announcements in Greek and International Conferences:

  1. Elias Christoforides, Kostas Bethanis, Athena Andreou, Aggelos Balios and Georgia Frygana. Crystallographic Analysis of Cannabidiol Inclusion Complexes with Native, Dimethylated, and Permethylated beta-Cyclodextrins (2023) 11th International Conference of the Hellenic Crystallographic Association (HeCrA23), October 20-22, Larisa, Greece (Oral presentation)
  2. Manio Skarlatou, Athena Andreou, Elias Christoforides and Trias Thireou. Analysis of the Structural Characteristics of the DNase1L3 enzyme’s R206C variant (2023) 11th International Conference of the Hellenic Crystallographic Association (HeCrA23), October 20-22, Larisa, Greece (Poster)
  3. Manio Skarlatou, Athena Andreou, Elias Christoforides and Trias Thireou. A Molecular Dynamics simulation study of the Arg206Cys variant in DNASE1L3 enzymes (2022) in Proceedings of the 2nd International Electronic Conference on Biomolecules: Biomacromolecules and the Modern World Challenges, session "Proteins" (IECBM2022), November 1–15, MDPI: Basel, Switzerland, Virtual Congress (Poster)
  4. Elias Christoforides, Andreas Papaioannou, Athena Andreou and Kostas Bethanis. Integrating “spicy” cyclodextrin inclusion complexes into the treatment of cancer: X-ray crystallographic analysis of piperine and capsaicin in native and methylated beta-cyclodextrins (2021), in Proceedings of the 7th International Electronic Conference on Medicinal Chemistry, session "Fighting cancer" (ECMC2021), November 1–30, MDPI: Basel, Switzerland, doi:10.3390/ECMC2021-11477, Virtual Congress (Poster)
  5. Elias Christoforides, Sophie Mavrikou, Andreas Papaioannou, Athena Andreou, Georgia Moschopoulou, Spyridon Kintzios and Kostas Bethanis. Structural and functional investigation reveals augment solubility and improved therapeutic index against SK-N-SH and HT29-MTX-E12 cells for Piperine inclusion complexes in native and modified β-Cyclodextrins (2021) 10th International Conference of the Hellenic Crystallographic Association (HeCrA21), October 15-17, NCSR Demokritos, Greece (Poster)
  6. Athena Andreou, Elias Christoforides, Kostas Bethanis and Elias E. Eliopoulos. Towards evolving carriers for small molecules with biological significance; A rational structural biological approach (2021) 10th International Conference of the Hellenic Crystallographic Association (HeCrA21), October 15-17, NCSR Demokritos, Greece (Poster)
  7. Evgenia Maria Politi, Elias Christoforides, Trias Thireou and Kostas Bethanis. Comparative structural evaluation of naringin and its aglycon, naringenin, as potential tyrosinase inhibitors using Molecular Docking and Molecular Dynamics analyses (2021) 10th International Conference of the Hellenic Crystallographic Association (HeCrA21), October 15-17, NCSR Demokritos, Greece (Poster)
  8. Elias Christoforides, Alexandros Balaouras and Michael Karpusas. Analysis of the effect of mutations on the structural dynamics and catalysis of the cyclophilin enzyme (2021) 10th International Conference of the Hellenic Crystallographic Association (HeCrA21), October 15-17, NCSR Demokritos, Greece (Poster)
  9. Kyriaki Hatziagapiou, Olti Nikola, Eleni Kakouri, George Lambrou, Kostas Bethanis, Elias Christoforides, Eleni Koniari, Petros Tarantilis, Christina Kanaka-Gantenbein. Integrating non psychoactive phytocannabinoids and their cyclodextrin inclusion complexes into the treatment of pediatric cancers (2021) 53rd Annual International Society of Paediatric Oncology Congress (SIOP2021), October 21-24, Virtual Congress (Poster)
  10. Kyriaki Hatziagapiou, Kostas Bethanis, Olti Nikola, Elias Christoforides,  Eleni Koniari, Eleni Kakouri, George Lambrou, Christina Kanaka-Gantenbein. Integrating non psychoactive phytocannabinoids and their cyclodextrin inclusion complexes into the treatment of Neuroblastoma (2021) 10th Europaediatrics Congress, October 7-9, Zagreb, Croatia (Poster)
  11. Kyriaki Hatziagapiou, Kostas Bethanis, Olti Nikola, Elias Christoforides, George Lambrou, Eleni Kakouri, Christina Kanaka-Gantenbein. Cyclodextrin inclusion complexes of cannabidiol for the treatment of glioblastoma (2021) 5th Minnesota NeuroOncology Virtual Symposium: Innovation of the Mind, May 17-18, Virtual Symposium (Poster)
  12. Kyriaki Hatziagapiou, Kostas Bethanis, Olti Nikola, Elias Christoforides, George Lambrou. Study of non-psychotropic phytocannabinoids and their encapsulation products in cyclodextrins as potential novel therapies for medulloblastoma (2020) 46th Annual Panhellenic Medical Conference, June 19-20, Athens, Greece, Online live presentation (Poster)
  13. Louis Papageorgiou, Athena Andreou, Elias Christoforides, Trias Thireou, Dimitrios Vlachakis, Elias E. Eliopoulos. Hippo(crates): The Openscreen-gr natural compounds database. An integrated atlas and pipelines of chemoinformatics for natural product exploration (2019) 70th National Conference of the Hellenic Society of Biochemistry & Molecular Biology (HSBMB19) November 29 – December 1, Eugenides Foundation, Athens, Greece (Poster)
  14. Nefeli Sofia D. Sotiropoulou, Katerina Fourtaka, Elias Christoforides, Christos Pappas, Kostas Bethanis and Petros A. Tarantilis. Inclusion of borneol, camphor and thujone monoterpens from sage infusion in native α- and β-cyclodextrin (2018) 30th International Symposium on the Chemistry of Natural Products and 10th International Congress on Biodiversity (ISCNP30 & ICOB10), November 25-29, Athens, Greece (Poster)
  15. Athena Andreou, Petros Giastas, Elias Christoforides and Elias Eliopoulos. Evolution through the crystal lens (2018) 9th International Conference of the Hellenic Crystallographic Association (HeCrA18), October 5-7, Patras, Greece (Oral)
  16. Elias Christoforides, Katerina Fourtaka, Nefeli Sofia D. Sotiropoulou, Christos Pappas, Petros Tarantilis and Kostas Bethanis. Structural studies on the encapsulation of Sage bicyclic monoterpenes in β-Cyclodextrin by X-ray crystallography and Molecular dynamics (2018) 9th International Conference of the Hellenic Crystallographic Association (HeCrA18), October 5-7, Patras, Greece (Poster)
  17. Katerina Fourtaka, Elias Christoforides, Dimitris Mentzafos, Athena Andreou and Kostas Bethanis. Inclusion complexes of citronellol with β-cyclodextrin, heptakis (2,6-di-O-methyl)-b-cyclodextrin and heptakis (2,3,6-tri-O-methyl)-β-cyclodextrin: an X-ray crystallographic study (2018) 2nd International Spring Meeting of HeCrA’s Young Researchers (HeCrA-Junior18), May 5-6, Department of Biochemistry & Biotechnology, University of Thessaly, Larissa, Greece (Oral)
  18. Kyriaki Hatziagapiou, Eleni Kakouri, Konstantinos Bethanis, Alexandra Nikola, Eleni Koniari, Charalabos Kanakis, Elias Christoforides, George Lambrou and Petros Tarantilis. Inhibitory Effects of Crocin from Crocus sativus L. on Cell Proliferation of a Medulloblastoma Human Cell Line (2017) World Academy of Science, Engineering and Technology, International Science Index, Medical and Health Sciences, 11(12), 3195–3195 (ICPOCP 2017) 19th International Conference on Pediatric Oncology and Clinical Pediatrics, December 14-15, Barcelona, Spain  (Poster)
  19. Elias Christoforides, Andreas Papaioannou, Katerina Fourtaka, Athena Andreou and Kostas Bethanis. Computational studies of the inclusion compound of Cholesterol in beta-cyclodextrin (2017) Proceedings of the 12th Conference of the Hellenic Society for Computational Biology and Bioinformatics (HSCBB17), October 11-13, Hellenic Pasteur Institute, Athens, Greece (Poster)
  20. Katerina Fourtaka, Elias Christoforides, Panagiotis Katinakis, Dimitris Mentzafos and Kostas Bethanis. Crystal structures and molecular dynamics simulations of inclusion compounds of lemongrass oil in native and methylated cyclodextrins. Study of their antimicrobial activity (2017) 5th European Conference on Cyclodextrin (EuroCD2017), October 3-6, Lisbon, Portugal (Poster)
  21. Elias Christoforides, Eleni Kakouri, Kyriaki Chatziagapiou and Kostas Bethanis. Inclusion of natural products with potential anticancer activity in cyclodextrins (2017) 5th European Conference on Cyclodextrin (EuroCD2017), October 3-6, Lisbon, Portugal (Poster)
  22. Elias Christoforides, Katerina Fourtaka, Andreas Papaioannou, Dimitris Mentzafos and Kostas Bethanis. Structural studies of cyclodextrin inclusion complexes by Χ-ray crystallography and molecular dynamics (2017) 1st International Spring Meeting of HeCrA’s Young Researchers (HeCrA-Junior17), May 27-28, National Hellenic Research Foundation (NHRF), Athens, Greece  (Oral Presentation)
  23. Katerina Fourtaka, Elias Christoforides, Dimitris Mentzafos, Panagiotis Katinakis and Kostas Bethanis. Crystallographic analysis of the inclusion compounds of cyclodextrins with bioactive substances (2017) 1st International Spring Meeting of HeCrA’s Young Researchers (HeCrA-Junior17), May 27-28, NHRF, Athens, Greece (Oral Presentation)
  24. Kyriaki Hatziagapiou, Maria Braoudaki, George Lambrou, Kostas Bethanis, Konstantina Yannakopoulou, Michael Karpusas, Frantzesca Tsorteki, Elias Christoforides, Vasilis Milionis, Fotini Tzortzatou-Stathopoulou and Vasiliki Gemou-Engesaeth. An innovative and targeted therapeutic approach to neuroblastoma: Gefitinib-cyclodextrin microencapsulation complexes (2016) 16th Annual Child Neurology Conference, December 9-10, Aegli Zappiou, Athens, Greece (Poster ΑΑ13)
  25. Kostas Bethanis, Elias Christoforides, Konstantina Yannakopoulou, Kyriaki Ηatziagapiou, Maria Braoudaki, Frantzeska Tsorteki, George I. Lambrou, Fotini Tzortzatou-Stathopoulou, Vasiliki Gemou-Engesaeth and Michael Karpusas. Structure and anti-proliferative activity of gefitinib-cyclodextrin complexes (2016) Proceedings of the Joint Conference of the Hellenic Crystallographic Association and the Hellenic Society for Computational Biology and Bioinformatics (HECRA-HSCBB16), October 7-9, Agricultural University of Athens, Athens, Greece (Oral presentation)
  26.  Katerina Fourtaka, Andreas Papaioannou, Elias Christoforides and Kostas Bethanis. Structural analysis of the inclusion compound of GA3 in permethylated-beta cyclodextrin (2016) Proceedings of the Joint Conference of the Hellenic Crystallographic Association and the Hellenic Society for Computational Biology and Bioinformatics (HECRA-HSCBB16), October 7-9, Agricultural University of Athens, Athens, Greece (Poster)
  27. Katerina Fourtaka, Elias Christoforides, Andreas Papaioannou and Kostas Bethanis. Crystal structure and Molecular Dynamics studies of inclusion compounds of agrochemicals and natural products in native and methylated beta cyclodextrins (2015) 4th European Cyclodextrin Congress (EuroCD2015), October 6 – 9, Lille, France (Poster)
  28. Elias Christoforides and Kostas Bethanis. Molecular Dynamic Simulation of Cyclodextrin supramolecular complexes (2014) Proceedings of the 9th conference of the Hellenic Society for Computational Biology & Bioinformatics (HSCBB14), October 10-12, Agricultural University of Athens, Athens, Greece (Poster)
  29. Kostas Bethanis, Vasso Triantafyllopoulou, Vassiliki Mazi, Elias Christoforides and Dimitris Mentzafos. Crystal structure of Auxin/Cyclodextrin inclusion complexes (2014) 7th Congress of Hellenic Crystallographic Association (HeCrA14), September 19-21, FORTH, Herakleion, Greece (Poster)
  30. Elias Christoforides, Maria Dimou, Panagiotis Katinakis, Kostas Bethanis and Michael Karpusas. Structural analysis of the bacterial enzymes Cyclophilin-A and Phosphate Acetyl Transferase (2012) 2nd Congress of Agricultural Biotechnology (abc2012), October 4-5, A.U.A, Athens Greece (Oral Presentation)
  31. Katerina Fourtaka, Elias Christoforides, Dimitris Mentzafos, Christos Pappas, Aimilia Eleni Nikolopoulou, Stella Tsagaropoulou and Kostas Bethanis Inclusion compound of IBA in β-Cyclodextrin. Preparation, characterization, crystal structure determination and application in plant seeds and vegetative material (2012) 6th International Conference of the Hellenic Crystallographic Association (HeCrA12), National and Kapodistrian University of Athens, September 28-29, Athens, Greece (Oral Presentation)
  32. Katerina Fourtaka, Nikos Chatziperos, Elias Christoforides, Areti Kokkinou and Kostas Bethanis. X ray Crystal Structure Analysis of the inclusion compounds of Borneol isomers in β-Cyclodextrin (2011) 21st Panhellenic Conference on Chemistry (21PSX), December 9-12, Thessaloniki, Greece (Oral Presentation)
  33. Katerina Fourtaka, Valia Boulaki, Elias Christoforides, Areti Kokkinou and Kostas Bethanis. X-ray Crystal Structure analysis of the inclusion compounds of Geraniol in native and permethylated β-Cyclodextrin (2011) 2nd European Conference on Cyclodextrins (EuroCD2011), October 2-4, Asti, Italy (Poster)
  34. Elias Christoforides, Maria Dimou, Panagiotis Katinakis, Kostas Bethanis and Michael Karpusas. Crystal Structure of the cyclophilin-A enzyme from Azotobacter vinelandii Acta Cryst. (2011) A67, C790 22nd Congress and General Assembly of the International Union of Crystallography (22IUCR), August 22-30, Madrid, Spain (Poster) 
  35. Elias Christoforides, Maria Dimou, Panagiotis Katinakis, Kostas Bethanis and Michael Karpusas. Crystal Structure of the cyclophilin-A enzyme from Azotobacter vinelandii (2010) 5th Congress of the Hellenic Crystallographic Association (HeCrA10), September 24-25, Larissa, Greece (Oral Presentation, 1st award «Nikos Oikonomakos»)
  36. Kostas Bethanis, Valia Boulaki, Elias Christoforides, Frantzeska Tsorteki, Areti Kokkinou and Dimitris Mentzafos. Crystal Structures of Geraniol Complexes with native and permethylated β-Cyclodextrin (2010) 5th Congress of the Hellenic Crystallographic Association (HeCrA10), September 24-25, Larissa, Greece (Poster)
  37. Elias Christoforides, Fransceska Tsorteki, Areti Kokkinou, Pavlos Tzamalis, Athanassios Hountas, Kostas Bethanis, Christos Pappas and Dimitrios Mentzafos. Crystal Structure of Cyclodextrin Complexes with Antioxidant Substances Acta Cryst A. (2009). A65, s258 25th European Crystallographic Meeting (25ECM), August 16-21, Instabul, Turkey (Poster)